Magnetic Microspheres: A Model System for Site Specific Drug Delivery in Vivo

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Abstract
A novel carrier system for the delivery of chemotherapeutic agents by magnetic means to desired sites was developed using Sprague-Dawley rats. The carrier, [human and bovine] albumin microspheres with entrapped Fe3O4, and adriamycin HCl, apparently can be concentrated at a predetermined site in vivo by a magnetic field. Carrier delivery of adriamycin is supported by the presence of a significant concentration of the drug at the site of carrier localization. This delivery system allows for the accumlation of local adriamycin which is comparable to that achieved by administration of a 100-fold higher dose of the free drug. [Toxicity of the microspheres containing Fe3O4 was measured by animal survival and histopathological studies using BDF, mice.].