Naloxone overcomes the dopaminergic, EEG, and behavioral effects of γ‐hydroxybutyrahe

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Abstract
The specific opiate antagonists—naloxone and naltrexone—attenuated or abolished the electrical seizure activity, behavioral abnormalities, and increased striatal dopamine content produced by γ-butyrolactone, the prodrug of γ-hydroxybutyrate. The effects of naloxone and naltrexone were dose-dependent. These data suggest that γ-hydroxybutyric acid exerts its effects by action either at the opiate receptor or on enkephalinergic systems, which may be involved in petit mal epilepsy.

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