Estrogen-Induced Uterine Hyperemia and Edema Persist during Histamine Receptor Blockade

Abstract
The effect of H1 and H2 histamine receptor antagonists [pyrilamine, burimamide] on estrogen-induced increases in [rat] uterine blood volume and uterine water content (edema) was determined. Neither the H1 or H2 histamine receptor antagonists nor the combination of both significantly altered either estrogen-induced increases in uterine blood volume or uterine water content. These results suggest that histamine does not play a major role in these physiological responses of the uterus to estrogen.