Application of an Original process for Obtaining Colloidal Dispersions of Some Coating Polymers. Preparation, Characterization, Industrial Scale-Up
- 1 January 1995
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 21 (2) , 229-241
- https://doi.org/10.3109/03639049509048106
Abstract
An original process for obtaining colloidal dispersions were used to prepare pseudolatex of coating polymers (Eudragit E 100 and Eudragit S 100). The method consists in introducing under magnetic stirring a solution of the polymers in a water-miscible solvent into an aqueous solution containing surfactant. In these conditions, polymers precipitate spontaneously in nanospheres. Investigations of some manufacturing parameters (initial polymer concentration, nature and concentration of surfactant) have allowed development of formulae for a semi-industrial seal-up. Characteristics of dispersions were also determined.Keywords
This publication has 1 reference indexed in Scilit:
- Aquesons Films Coating Stuied of Sustabined Release Niciotine Acid Fellets: An In-Vitro EvalutiionDrug Development and Industrial Pharmacy, 1992