EFFECT OF METOPIRONE ON THE SECRETORY RESPONSE OF THE TESTIS TO HUMAN CHORIONIC GONADOTROPHIN

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Abstract
Department of Pathophysiology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan (Received 16 December 1974) We have reported the inhibitory effect of methylenedianiline, a diaminodiphenyl derivative related to amphenone B, on the testicular 17-oxosteroid secretion stimulated by human chorionic gonadotrophin (HCG) (Yamashita, 1967). Unlike amphenone B (Rosenfeld & Bascom, 1956) and methylenedianiline (Tullner, 1960), Metopirone has been shown to be a relatively selective inhibitor of 11β-hydroxylase in the adrenal cortex (Liddle, Island, Lance & Harris, 1958). However, since it also is an amphenone analogue (Chart, Sheppard, Allen, Bencze & Gaunt, 1958), the present study was undertaken to see whether it exerts an amphenone-like effect on androgen synthesis and release by the testis. Spermatic venous blood was collected from 15 mongrel dogs, weighing between 7·9 and 13·1 kg, by the method described previously (Yamashita, 1966). In each dog the left spermatic vein was exposed by the lumbar route under

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