Circulating Vitamin D Metabolite Levels in Hypophosphatasia*
- 1 July 1982
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 55 (1) , 178-180
- https://doi.org/10.1210/jcem-55-1-178
Abstract
25OHD, 1,25-(OH)2D, and 24,25-(OH)2D were assayed in the serum of 16 patients with the infantile, childhood, or adult form of hypophosphatasia. Except for diminished 1,25- (OH)2D and elevated 24,25-(OH)2D levels in 2 infants (which could be attributed to nonparathyroid hormone-mediated hypercalcemia), the mean circulating level of each vitamin D metabolite was normal in the 3 patient groups. Abnormalities in vitamin D metabolism do not appear to contribute to the pathogenesis of this rare hereditary form of rickets or osteomalacia, which occurs despite normal circulating calcium, inorganic phosphate, and vitamin D metabolite levels.Keywords
This publication has 1 reference indexed in Scilit:
- Age-dependent variations in serum 1,25-dihydroxyvitamin D in childhoodActa Endocrinologica, 1980