EFFECT OF PROSTAGLANDIN-E1 ON HEMATOPOIESIS IN LONG-TERM BONE-MARROW CULTURES
- 1 January 1980
- journal article
- research article
- Vol. 8 (3) , 298-303
Abstract
The effect of prostaglandin E1 (PGE1) on the proliferation and differentiation of [mouse] hemopoietic stem cells was studied in a long-term bone marrow liquid culture system. In cultures supplemented with PGE1, there was a dose dependent decrease in both CFUs [pluripotential stem cells] and CFUc [granulocytic progenitor cells] CSA [colony stimulating activity] levels rose in a dose dependent manner, with a concomitant increase in mature granulocyte production. Macrophage production was suppressed. After cessation of PGE1 treatment, CFUs and CFUc returned gradually to the control values and CSA was not detectable. There was no significant effect on hemopoiesis in cultures supplemented with 10-8 M or less concentrations.This publication has 12 references indexed in Scilit:
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