Effects of Small Intravenous Doses of Epinephrine on Serum Insulin, Glucose Tolerance and Serum Free Fatty Acids

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Abstract
Eighteen intravenous glucose tolerance tests (IVGTT) were carried out in six young, normal subjects while they were receiving normal saline or epinephrine (E) intravenously at the low rates of 0.1 and 0.3 μgm. per minute. The lower dose of E caused changes in the rate of urinary excretion of free E similar to those caused by caffeine; the higher dose caused changes similar to those reported to occur during various moderate to severe stresses. The higher dose of E augmented the insulin response to IVGTT. Glucose tolerance was not significantly decreased, resulting in relatively low glucose-insulin ratios following glucose injection. Serum free fatty acids were unaffected.

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