Transduction of Penicillinase Production and Methicillin Resistance-Enterotoxin B Production in Strains of Staphylococcus aureus

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Abstract
Summary: It is suggested that wild strain DU4916 of Staphylococcus aureus harbours at least two plasmids. One of them is responsible for penicillinase production and resistance to metallic ions and the other for methicillin and cephalothin resistance together with enterotoxin B production. These properties were eliminated en bloc with acridines as well as separately at different rates. Transductions were performed to restore the eliminated characters with typing phages 29 and 88. Recombination of the markers for penicillinase production and methicillin resistance on the transduced fragment seems advantageous for selection of methicillin resistance.