Highly Diastereoselective Titanocene Catalysed Pinacol Couplings
- 1 April 1997
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1997 (4) , 363-364
- https://doi.org/10.1055/s-1997-795
Abstract
A novel catalytic pinacol coupling utilising 3 mol % of the readily available rac-ethylenebis(η5-tetrahydroindenyltitanium) dichloride (EBTHITiCl2) as catalyst is described. Diastereoselectivities are in excess of 95:5. The reaction conditions for the coupling of aromatic aldehydes are mild and tolerate a variety of functional groups interfering with dihydroxylation reactions and McMurry coupling reactions.Keywords
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