HLA Frequencies in a Mexican Mestizo Population

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Abstract
The distribution of HLA antigens in Mexican Mestizos was reevaluated since very few specificities were previously explored for this population. The Mestizos are primarily a mixture of Caucasians (Spaniards) and Mexican Indians and account at the present time for about 95% of the total Mexican population. HLA-A and -B antigens were typed on isolated cells using a microlymphocytotoxicity technique. Antigen, gene and haplotype frequencies were calculated including the significance for .DELTA. values. The HLA distribution differed from other ethnic groups and the predominant antigens were A2, A9, B5, Bw35 and B40, but the general pattern clearly showed the participation in genetical composition of Spanish and Mexican Indian backgrounds. The most frequent haplotypes were A2-B5, A9-Bw35, A9-B40 and A2-B40, which are also the most common in some Mongoloid populations.