Urinary Excretion of Sodium and Chloride After Splanchnicotomy; Effect on the Proximal Tubule

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Abstract
Excretion of Na and chloride was studied in 3 dogs under conditions of osmotic diuresis in hydropenia following unilateral splanchnicotomy. The loading solute was 10% NaCl. Renal excretion of Na, chloride and water on the operated side markedly exceeded that on the control side. These increases were independent of any increase in glomerular filtration rate or renal plasma flow on the operated side. The results are consistent with the assumption that the process, whereby the urine content of Na and chloride is assembled by the renal tubules, is subject to control by the splanchnic nerve.

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