Comparison of Philadelphia Chromosome-Positive and -Negative Patients with Chronic Myelocytic Leukemia
- 1 October 1964
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 61 (4) , 625-635
- https://doi.org/10.7326/0003-4819-61-4-625
Abstract
Discovery of the Philadelphia chromosome (Ph1) in cases of chronic myelocytic leukemia (1) provided the first demonstration of a specific chromosomal abnormality in a human neoplasm. However, this abnormal cytogenetic feature is not present in all cases of this disorder, and a small number of patients said to be typical otherwise, but lacking the Ph1 chromosome, have been described (2). Since 1961, cytogenetic studies have formed part of the initial and subsequent hematologic investigation of patients with chronic myelocytic leukemia seen at this Institute. During this time, we have observed and treated both Ph1+ and Ph1- patients. The contrasts betweenKeywords
This publication has 3 references indexed in Scilit:
- The Effect of Treatment in Patients with Chronic Myelogenous LeukemiaAnnals of Internal Medicine, 1963
- Cytogenetic Studies in Chronic Myeloid LeukemiaPublished by Elsevier ,1963
- Agnogenic Myeloid MetaplasiaAnnals of Internal Medicine, 1962