The men of Peru''s sierra and the inhabitants of the coast, besides being physiologically different, live in 2 different worlds. This psychosomatic difference results, when the mechanisms of adjustment fail, in the sindrome psicosomatico de desadaptacion. When it is not correctly diagnosed the patient is bound to be mishandled and aggravated. Etiology, symptomatology, clinical pictures, pathogenesis, evolution diagnosis, prognosis, and therapy of the sindrome psicosomatico de desadaptacion are studied.