Altering prion replication for therapy and diagnosis of transmissible spongiform encephalopathies

1 August 2002

journal article
Published by Portland Press Ltd. in Biochemical Society Transactions

Vol. 30 (4) , 569-573
https://doi.org/10.1042/bst0300569

Abstract

Transmissible spongiform encephalopathies, also known as prion-related diseases, are a group of fatal neurodegenerative disorders associated with the misfolding of the prion protein. In this article, the potential use of the principles of prion replication to develop novel therapeutic and diagnostic strategies for these devastating diseases are described.

Keywords

BOVINE SPONGIFORM ENCEPHALOPATHY
CREUTZFELDT-JAKOB DISEASE
PROTEIN MISFOLDING
SCRAPIE
CJD
TSE
TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY
PMCA
PROTEIN MISFOLDING CYCLIC AMPLIFICATION

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