A new tetra-lactam host compound and its complexes with ethanol and dimethyl sulfoxide

Abstract
The 32-membered tetra-lactam host compound 1 is synthesized in 26 % yield by the ring formation reaction of glutaryl dichloride with the diamido-diamine 2 using high dilution conditions. X-Ray crystal structure analyses of complexes of 1 with ethanol (EtOH) (1a) and dimethyl sulfoxide (DMSO) (1b) with unusual host:guest stoichiometric ratios (1:4 for 1a and 1:6 for 1b) are reported showing specific modes of host-guest hydrogen bonding.