Abstract
Three patients showed a growing choroidal melanoma, of them 2 in the only eye. The tumors were treated with Ru106/Rh106 plaques and surrounded by argon or krypton photocoagulation. The patients were followed up for 34-36 mo. by regular fluorescein angiography. In areas in which the radiation effect was optimal most choroidal and retinal vessels disappeared within 3-6 mo. Outside this area occlusion of the vasculature as well as progressing atrophy of the tumor and the overlying retinal pigment epithelium were seen to continue for more than 12 mo. after treatment. Disappearance of the leaking vessels of the tumor may be the most reliable fluorescine angiographic sign of tumor regression following conservative treatment.