The effect of trypsin on membrane transport of non‐electrolytes

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Abstract
Trypsinization of alveolar macrophages depresses lysine transport but has no effect on nucleoside transport. The depression of the initial rate of lysine transport is due to a decreased rate of exchange diffusion presumably secondary to lowered intracellular pools of amino acids. It is shown directly that trypsinization accelerates the efflux of amino acids but not certain other metabolites, and reduces the capacity of the cell to concentrate amino acids.