In vivo and in vitro Effects of Alloxan on Collagen Characteristics of Bone, Skin and Tendon of Swiss Mice

1 January 1979

journal article
research article
Published by S. Karger AG in Gerontology

Vol. 25 (5) , 255-260
https://doi.org/10.1159/000212350

Abstract

Alloxan diabetes in Swiss mice induced decreased levels of percent solubility of collagen in bone, skin and tendon both after 4 days (96 h) and 28 days of treatment. In vitro treatment of tissues with alloxan in physiological saline did not influence the cross-linking of collagen. It is suggested that in alloxan diabetes, metabolites formed in the tissues might accelerate aging of collagen.

Keywords

This publication has 4 references indexed in Scilit:

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Biochemical and Biophysical Research Communications, 1977
Aging of the Collagen Fiber
Published by Elsevier ,1964
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