Novel antitumor antibiotics, CI-940 (PD 114,720) and PD 114,721. Taxonomy, fermentation and biological activity.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (4) , 460-465
- https://doi.org/10.7164/antibiotics.38.460
Abstract
The novel, broad-spectrum antitumor antibiotics, CI-940 (PD 114,720) and PD 114,721, are components of bioactive compounds produced by a novel actinomycete (ATCC 39366). The organism is unique in that whole cell analysis revealed LL-diaminopimelic acid and major amounts of arabinose. These new antibiotics exhibit potent antitumor activity in vitro and in vivo vs. an array of tumors and possess strong antibacterial and antifungal activity. The above antibiotics are produced in 7570-l fermentors at yields of .apprx. 5-8 .mu.g/ml.This publication has 1 reference indexed in Scilit:
- A COBALT-CONTAINING MEDIUM FOR SPORULATION OF STREPTOMYCES SPECIESJournal of Bacteriology, 1952