Blood Vascular System in Cancer of the Larynx
- 1 February 1976
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 102 (2) , 65-70
- https://doi.org/10.1001/archotol.1976.00780070043001
Abstract
• Injection methods were used for the study of the blood vascular system in 50 specimens from total or subtotal laryngectomy in patients with extensive cancer of the larynx, and in 24 normal postmortem larynges. All specimens were injected via the superior laryngeal arteries. A silicone rubber technique was found to be the most suitable for the aims of this study. A chaotic distribution of abnormal vessels that differ in shape, a rich neovascular network within the tumor, and capillary hypertrophy in its vicinity are the main features of the blood vascular system in laryngeal cancer. The results obtained indicate great tumor-angiogenic ability that can be indirectly explained by action of an angiogenesis factor diffusing from cancer cells. This may open new possibilities for the treatment of carcinoma of the larynx based on anti-angiogenesis. (Arch Otolaryngol 102:65-70, 1976)Keywords
This publication has 4 references indexed in Scilit:
- Tumor Angiogenesis: Transfilter Diffusion Studies in the Hamster by the Transparent Chamber Technique2JNCI Journal of the National Cancer Institute, 1968
- Vasculae Reactions of Normal and Malignant Tissues in Vivo. I. Vascular Reactions of Mice to Wounds and to Normal and Neoplastic TransplantsJNCI Journal of the National Cancer Institute, 1945
- HETEROLOGOUS TRANSPLANTATION OF MAMMALIAN TUMORSThe Journal of Experimental Medicine, 1941
- Histologie der Luftwege und der MundhöhlePublished by Springer Nature ,1925