Studies of the Reticuloendothelial System (RES). III. Blockade of the RES in Man *

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Abstract
Blockade of the reticulo-endothelial system (RES) in man was produced safely and effectively by the administration of large doses of either aggregated human serum albumin or gelatin. Blockade of the RES was relatively specific, since the clearance of similar particles was inhibited to a greater degree and for longer duration than the clearance of dissimilar particles. Specificity was not absolute, since a blockading effect of shorter duration and lesser magnitude was observed with dissimilar particles.