UNEXPECTED REACTION OF INTRACELLULAR PH FOLLOWING THERAPY OF ACID-BASE STATUS BY ARGININE-HYDROCHLORIDE
- 1 January 1983
- journal article
- research article
- Vol. 32 (11) , 532-537
Abstract
A well known complication following [human] surgical intervention is metabolic alkalosis. In general this acid-base disturbance is treated in intensive care units by application of arginine-hydrochloride. In an experimental study on rats in vivo the influence of this substance on the acid-base status of the extra- and intracellular body compartment was determined. The extracellular HCO3- decreased but there was nearly no influence on intracellular buffering. The mean whole body pHi, an overall estimate of the intracellular pH as complementary to the in vivo determined extracellular plasma pH, was determined with DMO (5,5-dimethyl-2,4-oxazolidinedione) and shown to increase significantly after application of arginine-hydrochloride. Apparently, arginine-hydrochloride should not be used for clinical therapy of metabolic alkalosis.This publication has 7 references indexed in Scilit:
- Comparison of Intra- and Extracellular Buffering of Clinically Used Buffer Substances: Tris and BicarbonateActa Anaesthesiologica Scandinavica, 1982
- Appearance of calcium action potentials in crayfish slow muscle fibres under conditions of low intracellular pH.The Journal of Physiology, 1980
- Respiratory gas exchange in the rat spleen in situ and intrasplenic oxyhemoglobin saturationPflügers Archiv - European Journal of Physiology, 1979
- Intracapillary hemoglobin oxygen saturation and oxygen consumption in different layers of the left ventricular myocardiumPflügers Archiv - European Journal of Physiology, 1977
- INTRACELLULAR ACID‐BASE RELATIONS AND INTRACELLULAR BUFFERSAnnals of the New York Academy of Sciences, 1961
- The Quantitative Determination of Surplus Amounts of Acid or Base in the Human BodyScandinavian Journal of Clinical and Laboratory Investigation, 1960
- CALCULATION OF INTRACELLULAR pH FROM THE DISTRIBUTION OF 5,5-DIMETHYL-2,4-OXAZOLIDINEDIONE (DMO). APPLICATION TO SKELETAL MUSCLE OF THE DOG*Journal of Clinical Investigation, 1959