Live Poliomyelitis Virus Vaccines

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Abstract
NOW THAT RESEARCH in vaccination with live attenuated polioviruses goes back 11 years,1 to the year of the first experimental inoculation in man, it can be said that live virus vaccination is approaching its adolescence. During its childhood considerable research was done in strain selection, mechanism of immunization, genetic markers, and capacity to spread; then came the gradual increase in the numbers of persons vaccinated—from tens to thousands to millions. The child was obviously a prodigy; now many of the important parameters of successful vaccination are known, such as dosage, infection rate, antibody response, influence of age, value of monovalent versus trivalent administration, factors that influence age, value of monovalent versus trivalent administration, factors that influence spread, and so on. In field trials unparalleled in magnitude, approximately 100 million persons were given live virus in order that the action of the attenuated virus might be studied. The results already

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