Enantiomeric resolution of DNS‐amino acids by ligand exchange chromatography: Comparison of different chiral amino acid amides as additives to the mobile phase
- 1 January 1990
- Vol. 2 (3) , 190-193
- https://doi.org/10.1002/chir.530020311
Abstract
A study developing enantiomeric separations by metal chelate additives to the mobile phase in reversed‐phase liquid chromatography is reported. In particular the use of Cu(II) complexes of L‐prolinamide (L‐ProNH2) and L‐valinamide (L‐ValNH2) is examined and discussed. Interestingly, for a series of DNS‐amino acids these selectors show higher enantioselectivity than that obtained with the corresponding nonderivatized amino acid–Cu(II) complexes.Keywords
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