RADIO-FIBRINOGEN CATABOLISM STUDIES IN HUMAN RENAL ALLOGRAFT RECIPIENTS

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Abstract
SUMMARY Fifty-five radio-fibrinogen eatabolism studies have been performed in patients with renal allografts to assess their use in the evaluation of rejection. In the postoperative period, accelerated fibrinogen catabolism was found until the 3rd week. Nevertheless, rejection occurs in most patients at this stage and the response to heparinisation shows that the accelerated catabolism is attributable to intravascular coagulation; the effect is not attributable to high dose corticosteroids. At three to nine months of allograft survival, patients with rejection also showed increased fibrinogen catabolism; those who did not were already on antiplatelet and anticoagulant therapy. Seven of ten long-term survivors with normal renal function had normal catabolism; the three who were abnormal had polycystic kidneys. The test is a sensitive monitor of vascular rejection and will therefore be of use in monitoring new forms of therapy.

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