Enhancement of Ethanol Toxicity by Ethacrynic Acid
- 1 April 1965
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 118 (4) , 970-973
- https://doi.org/10.3181/00379727-118-30019
Abstract
Summary Treatment with ethacrynic acid increases the lethality of ethanol in mice. Dogs treated with ethacrynic acid and ethanol have higher venous blood alcohol concentrations than those given alcohol alone, Ethacrynic acid has been demonstrated to be a weak in vitro inhibitor of alcohol dehydrogenase. Mechanism of action and possible clinical significance have also been discussed.Keywords
This publication has 2 references indexed in Scilit:
- Ethacrynic Acid: Diuretic Property Coupled to Reaction with Sulfhydryl Groups of Renal CellsScience, 1964
- Effects of Silver and Mercurials on Yeast Alcohol DehydrogenaseJournal of Biological Chemistry, 1960