Mouse monoclonal antibodies specific for M and N blood group-related antigens.
- 1 January 1987
- journal article
- Published by Japan Society of Transfusion Medicine and Cell Therapy in Journal of the Japan Society of Blood Transfusion
- Vol. 33 (1) , 21-26
- https://doi.org/10.3925/jjtc1958.33.21
Abstract
Eleven examples of mouse monoclonal antibodies were produced with specificities related to human blood group MN antigens. The eleven monoclonal antibodies, comprising eight which react with M antigen and three with N antigen, react in direct hemagglutination system, and their specificities were investigated by their reaction with panel and enzyme-modified red cells. The antibodies were used, in parallel with conventional polyclonal anti-M and anti-N sera, to type a series of random blood donors. The results obtained with the monoclonal antibodies and the polyclonal reagents were in perfect agreement. The monoclonal anti-M and anti-N antibodies could prove to be valuable alternatives to conventional reagents used currently for MN-blood grouping.Keywords
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