Isolation and identification of an in vivo reaction product of 6-hydroxydopamine

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Abstract
The product of oxidized 6-OHDA [6-hydroxydopamine] and GSH [glutathione] reacted in vitro was identified by a variety of chemical and physical methods to be 2,4,5-trihydroxy-6-S-(glutathionyl)phenethylamine. Its chemical properties showed it easily underwent a variety of oxidative condensations and polymerization. Its oxidized form, the p-quinone, was identified in small quantities in rat brain and mouse brain 1-3 h after 6-OHDA injection. This is believed to be the 1st report of a chemically identified species resulting from the in vivo interaction of 6-OHDA with CNS tissue.