Ki-67 Immunoreactivity, Ploidy and S-Phase Fraction as Prognostic Factors in Patients with Gastric Carcinoma
- 1 January 1996
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 53 (3) , 182-191
- https://doi.org/10.1159/000227558
Abstract
Expression of the Ki-67 antigen was determined by immunohistochemical analysis of paraffin-embedded specimens from 242 patients with gastric adenocarcinoma and the prognostic value of Ki-67 immunoreactivity was compared with ploidy and S-phase fraction (SPF) obtained by DNA flow cytometry. A high percentage of Ki-67 immunostaining was associated with the intestinal type of cancer (p = 0.0002) and male sex (p = 0.003), but correlated only weakly with the SPF (rs = 0.343) and not at all with ploidy. The intestinal type of gastric carcinoma was more frequently aneuploid and had a higher SPF than diploid tumours (pKeywords
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