Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities
Top Cited Papers
- 15 June 2004
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 113 (12) , 1664-1675
- https://doi.org/10.1172/jci200422147
Abstract
Chronic and excessive inflammation in skin and joints causes significant morbidity in psoriasis patients. As a prevalent T lymphocyte–mediated disorder, psoriasis, as well as the side effects associated with its treatment, affects patients globally. In this review, recent progress is discussed in the areas of genetics, the immunological synapse, the untangling of the cytokine web and signaling pathways, xenotransplantation models, and the growing use of selectively targeted therapies. Since psoriasis is currently incurable, new management strategies are proposed to replace previous serendipitous approaches. Such strategic transition from serendipity to the use of novel selective agents aimed at defined targets in psoriatic lesions is moving rapidly from research benches to the bedsides of patients with this chronic and debilitating disease.Keywords
This publication has 103 references indexed in Scilit:
- A RUNX trio with a taste for autoimmunityNature Genetics, 2003
- p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseasesNature Reviews Drug Discovery, 2003
- Points of control in inflammationNature, 2002
- Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLPNature Immunology, 2002
- Disease concomitance in psoriasisJournal of the American Academy of Dermatology, 1995
- Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skinJournal of the American Academy of Dermatology, 1994
- Remission of psoriatic lesions with muromonab-CD3 (Orthoclone OKT3) treatmentJournal of the American Academy of Dermatology, 1989
- Immunologic mechanisms in psoriasisJournal of the American Academy of Dermatology, 1988
- Psoriasis of early and late onset: Characterization of two types of psoriasis vulgarisJournal of the American Academy of Dermatology, 1985
- PsoriasisJournal of the American Academy of Dermatology, 1984