Neuropathy in igM? paraproteinemia
- 1 January 1989
- journal article
- research article
- Published by Springer Nature in Acta Neuropathologica
- Vol. 78 (1) , 57-64
- https://doi.org/10.1007/bf00687403
Abstract
In axonal neuropathies associated with IgM paraproteinemia, reports of antigen specificity of the M-protein are few. A patient with IgM paraproteinemia presented with progressive mononeuritis multiplex. IgM was found deposited in striking amounts in endoneurium and shown to bind specifically to neural proteins and chondroitin sulfates. Direct immune mechanisms, as well as the physical effects of IgM deposition, likely contributed to the development of the neuropathy.Keywords
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