Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2‐Arachidonoylglycerol
- 28 May 2009
- journal article
- research article
- Published by Wiley in ChemMedChem
- Vol. 4 (6) , 946-950
- https://doi.org/10.1002/cmdc.200800442
Abstract
Biosynthesis Inhibition: O‐5596, a new inhibitor of the biosynthesis of the endocannabinoid, 2‐arachidonoylglycerol, was synthesized and found to be potent (IC50=100 nM) and selective versus other proteins and enzymes of the endocannabinoid system in vitro and active in vivo at reducing food intake in mice. magnified imageKeywords
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