The calcium cyanamide--ethanol interaction in man. Effects of repeated ethanol administration.

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Abstract
Five men alcoholics, consuming alcohol (0.4 g/kg of body weight) 10 h after 0.7 mg of citrated calcium cyanamide (CC) per kg of body weight, had increased blood acetaldehyde, accompanied by tachycardia, facial flushing and lowered diastolic blood pressure. A 2nd alcohol dose (also 0.4 g/kg) 3.5 h later had only mild effects, significantly lower in magnitude than those after the 1st dose. Significant positive correlations were found between blood alcohol concentration and blood acetaldehyde level and between blood acetaldehyde and symptom changes after the 1st but not the 2nd dose. The clinical implication of the findings, i.e., that alcoholics can burn off the CC by slowly ingesting alcohol over a few hours and thereafter can drink with impunity, are discussed.

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