Involvement of K+ channels in the quercetin-induced inhibition of neuroblastoma cell growth
- 1 May 1993
- journal article
- excitable tissues-and-central-nervous-physiology
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 423 (3-4) , 202-205
- https://doi.org/10.1007/bf00374395
Abstract
The effects of the flavonoid quercetin on cell proliferation and voltage-dependent K+ current were studied on mouse neuroblastoma×glioma hybrid cells. In the presence of 1 % fetal calf serum, quercetin inhibited both cell proliferation and K+ current with effective doses inducing half-maximum effects of 10 μM and 70 μM respectively. Valinomycin (1 nM) antagonized 80 % of the growth-inhibitory effects of 10 μM quercetin. The results suggest that at least a part of the antiproliferative effect of quercetin is mediated by a K+ channel blockade. They further confirm a role for K+ channels in mitogenesis and cell proliferation.Keywords
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