Innervation of rat antral gastrin-producing cells

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Abstract
The innervation of rat antral gastrin‐producing cells (G‐cells) was studied by light and electron microscopy. Combination of histochemistry for acetylcholinesterase and immunofluorescence for gastrin in the same tissue section showed apparent contact between some of the G‐cells and acetylcholinesterase‐positive nerves. Electron microscopic observation, however, revealed gaps of 200–500 nm or more between the G‐cells and the closest nerve axons which often contained large dense‐cored vesicles. The latter may represent the storage sites for neuropeptides previously localized by immunohistochemistry in gastric nerves.