Comparison of Two Dosage Schedules of Doxycycline in Children with Rickettsial Spotted Fever
- 1 June 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 155 (6) , 1215-1219
- https://doi.org/10.1093/infdis/155.6.1215
Abstract
We carried out a randomized clinical trial with oral doxycycline in children with Israel rickettsial spotted fever. Our purpose was to investigate whether an abbreviated course of therapy with this drug (until the patient was afebrile plus one day) would be as effective as a one-week regimen of therapy. Results with 50 pediatric patients during this three-year study indicated that the abbreviated treatment regimen was as effective. This clinical trial may serve as a model for determining shorter durations of therapy for other diseases.Keywords
This publication has 1 reference indexed in Scilit:
- Rocky Mountain Spotted Fever: Epidemiology of an Increasing ProblemAnnals of Internal Medicine, 1976