RENEWED INTEREST IN GASES FOR CONTRAST ROENTGENOGRAPHY

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Abstract
Four groups of dogs were subjected to intravenous injections of room air, nitrous oxide, and carbon dioxide at injection rates employed clinically in gas contrast roentgenography in order to compare lethal volumes and concentrations. Intravenously injected room air produced death in concentrations similar to those previously reported. Intravenously injected nitrous oxide and carbon dioxide produced death in concentrations and volumes only 3 times greater than air. The volume of carbon dioxide required to produce death was increased 3 times when dogs placed in the left lateral decubitus position were compared with those placed in the supine position. Lethal effects were produced in all dogs injected intravenously with gas at a rate employed in clinical gas roentgenography. Although the absorption coefficients of carbon dioxide and nitrous oxide are 20 times greater than air and oxygen, the safety factor of clinically employed volumes of gas is closer to 3. When introducing relatively large volumes of carbo...

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