Effects of orbital prefrontal cortex dopamine depletion on inter-temporal choice: a quantitative analysis
- 27 February 2004
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 175 (2) , 206-214
- https://doi.org/10.1007/s00213-004-1813-y
Abstract
Lesions of the orbital prefrontal cortex (OPFC) can cause pathologically impulsive behaviour in humans. Inter-temporal choice behaviour (choice between reinforcers differing in size and delay) has been proposed as a model of “impulsive choice” in animals. We recently found that destruction of the OPFC disrupted inter-temporal choice in rats. It is not known whether the dopaminergic projection to the OPFC contributes to the regulation of inter-temporal choice.Keywords
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