Chromosome-Sized DNA Molecules of Plasmodium falciparum
- 16 August 1985
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 229 (4714) , 658-661
- https://doi.org/10.1126/science.3895435
Abstract
At least seven chromosome-sized DNA molecules (750 to 2000 kilobases in length and one fraction of undetermined molecular weight) from cultured clones and isolates of Plasmodium falciparum have been separated by pulsed-field gradient gel electrophoresis. Whereas asexual blood stages and sexual stages of the same line have identical molecular karyotypes, the length of chromosome-sized DNA molecules among different geographical isolates and several clones derived from a single patient is different. These length alterations of chromosomes are the result of DNA rearrangements that must occur unrelated to sexual differentiation.Keywords
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