Association of Coronary Risk Factors and Endothelium-Dependent Flow-Mediated Dilatation of the Brachial Artery.
Open Access
- 1 January 2000
- journal article
- clinical trial
- Published by Japanese Society of Hypertension in Hypertension Research
- Vol. 23 (3) , 233-238
- https://doi.org/10.1291/hypres.23.233
Abstract
Impaired endothelial function has been reported to be the initial step in atherosclerosis. Some coronary risk factors independently relate to impaired endothelial function. However, few studies have examined the association between coronary risk factors and endothelial function in patients who have multiple risk factors without clinical atherosclerosis. This study was undertaken to elucidate the relationship between accumulation of coronary risk factors and vascular endothelial dysfunction. We examined 101 subjects with one or more coronary risk factors 56.8±1.0 years old and 40 age-matched control subjects without coronary risk factors. We measured brachial artery diameter non-invasively using a 7.5-MHz ultrasound machine at rest, during reactive hyperemia caused by endothelium-dependent vasodilatation, and after sublingual administration of nitroglycerin, which causes endothelium-independent vasodilatation. The percentage change in flow-mediated diameter (%FMD; ΔD/D×100), in subjects with one or more coronary risk factors was significantly lower than that in control subjects (4.8±0.3% vs. 6.7±0.5% pHyperfens Res 2000; 23: 233-238)Keywords
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