HISTOLOGICAL AND CLINICAL FINDINGS IN 896 CONSECUTIVE PROSTATES TREATED ONLY WITH RADICAL RETROPUBIC PROSTATECTOMY: EPIDEMIOLOGIC SIGNIFICANCE OF ANNUAL CHANGES

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Abstract
Conclusions We believe that the extraordinary rise and fall in prostate cancer detection rates from 1990 to 1994 primarily removed previously undetected T2 cancers from the pool at large, leaving impalpable T1c cancers as the primary reservoir of prostate cancers in the United States. Importantly, cancer volume, percent Gleason grade 4/5 cancer, serum PSA and cancers less than 0.5 cc have not had a highly significant change during these critical 9 years. These data argue strongly that current PSA testing has not resulted in the detection of clinically insignificant cancers, and that PSA screening should be expanded and not restricted.

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