Nucleophilic substitution reactions of allylic halides carrying electron-withdrawing substituents in the γ-position. Formation of cyclopropanes from dimethyl 2-bromo-2-methylpropylidenemalonate
- 1 January 1972
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 7,p. 375
- https://doi.org/10.1039/c39720000375
Abstract
Reaction of dimethyl 2-bromo-2-methylpropylidenemalonate with sodium methoxide or potassium cyanide in methanol produces cyclopropane derivatives in high yields, thus indicating an overall substitution with nucleophilic attack occurring at the β-position of the allylic halide.Keywords
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