ERK1/2 MAP kinases in cell survival and apoptosis
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Open Access
- 1 November 2006
- journal article
- review article
- Published by Wiley in IUBMB Life
- Vol. 58 (11) , 621-631
- https://doi.org/10.1080/15216540600957438
Abstract
ERK1/2 is an important subfamily of mitogen‐activated protein kinases that control a broad range of cellular activities and physiological processes. ERK1/2 can be activated transiently or persistently by MEK1/2 and upstream MAP3Ks in conjunction with regulation and involvement of scaffolding proteins and phosphatases. Activation of ERK1/2 generally promotes cell survival; but under certain conditions, ERK1/2 can have pro‐apoptotic functions. iubmb Life, 58: 621 ‐ 631, 2006Keywords
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