Interaction of Ethanol and Thyroxine on Hepatic Oxygen Consumption

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Abstract
The interrelationship between the effects of chronic ethanol ingestion and T4 thyroxine treatment on O2 consumption by rat liver slices and isolated mitochondria was investigated. The ethanol influence on O2 consumption by liver slices was dependent on the available oxidizable substrate; the oxidizable substrate was decreased when estimated in media containing glucose but increased in media containing succinate. The respiration of thyrotoxic rat liver slices was altered by ethanol similar to that observed with euthyroid rat liver slices. Whereas ethanol ingestion enhanced succinate-supported respiration of euthyroid and thyrotoxic rat liver slices, it produced a similar effect in isolated mitochondria of thyrotoxic rat livers but not of euthyroid rat livers.

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