Effects of Nitric Oxide Synthase Inhibitors on Gastric Alkaline Secretion in Rats.
- 1 January 1992
- journal article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 60 (3) , 303-305
- https://doi.org/10.1254/jjp.60.303
Abstract
The effects of NG-nitro-L-arginine methyl ester (L-NAME), the nitric oxide (NO) synthase inhibitor, on gastric HCO3- secretion were examined in anesthetized rats. Intravenous administration of L-NAME (1, 2.5, 5 mg/kg) increased HCO3- secretion in a dose-related manner. This effect of L-NAME was mimicked by NG-mono-methyl-L-arginine (50 mg/kg, i.v.) and was antagonized significantly by concurrent administration of L-arginine but not D-arginine (200 mg/kg, i.v.). These results indicate that gastric HCO3- secretion is stimulated by inhibition of NO biosynthesis.Keywords
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