Antithiamine Effect of Oxythiamine and Neopyrithiamine. A Comparative Study
- 12 August 1949
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 110 (2850) , 162
- https://doi.org/10.1126/science.110.2850.162
Abstract
Daily injn. of oxythiamine into 9 mice on thiamine free diet receiving 1 [mu]g. of thiamine subcut. each day for maintenance resulted in an immediate loss of wt., but no polyneuritis; survival time ranged from 13 to 21 days. The dosage of oxythiamine was 50 [mu]g./day administered with the thiamine. Similar treatment of an equal number of animals with neopyrithiamine not only resulted in immediate loss of wt., but in 100% incidence of polyneuritis, and survival time was but 7-8 days.Keywords
This publication has 1 reference indexed in Scilit:
- Vitamin Requirements of the MousePublished by Elsevier ,1947