Effect of Lysine Provided by Different Routes on Cariogenicity of Lysine Deficient Diet

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Abstract
A supplement of L-lysine in food, or water, and by intubation, given to white rats receiving a cariogenic, lysine-deficient diet, significantly inhibited smooth surface dental caries. Although L-lysine as given by intraperitoneal injection was utilized for growth, it did not clearly inhibit caries. The reduction in caries by intubated L-lysine suggests that a systemic extra-oral action may account for the result. The fact that injected L-lysine did not increase the lysine in rats'' saliva (above 1.0 mg %) adds support to this hypothesis.

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