Platelet glyoxalases in thrombocytosis
- 1 July 1984
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 33 (1) , 91-94
- https://doi.org/10.1111/j.1600-0609.1984.tb02216.x
Abstract
In platelets of patients suffering from thrombocytosis due to myeloproliferative disorders, glyoxalase I activity is significantly higher than in controls (P < 0.01), while glyoxalase II levels are the same (P < 0.3). The endocellular concentration of glutathione is also increased in patients. Km values for methylglyoxal (glyoxalase I) and S-lactoylglutathione (glyoxalase II) are identical both in normal and pathological subjects, as are the thermostability of the 2 enzymes. The higher activity observed for glyoxalase I in patients could be related to a specific role of this enzyme in platelets.Keywords
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