Opioid Peptides Modulate Luteinizing Hormone Secretion During Sexual Maturation
- 16 March 1979
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 203 (4385) , 1129-1131
- https://doi.org/10.1126/science.424743
Abstract
Subcutaneous injections of naloxone, an opiate antagonist, lead to an increase in serum luteinizing hormone concentrations in female but not in male rats before they reach puberty. In addition, estradiol benzoate specifically blocks the luteinizing hormone response to naloxone in prepubertal female rats, suggesting that the opioid peptides have a physiological role in the endocrine events leading to sexual maturation.This publication has 18 references indexed in Scilit:
- Opiate analgesics: the effect of agonist-antagonist character on prolactin secretionJournal of Pharmacy and Pharmacology, 1978
- Regulation of prolactin release by endogenous opiatesNature, 1977
- The development of the hypothalamo–pituitary axis in the neonatal rat: sexual maturation in male and female rats as assessed by hypothalamic LHRH and pituitary and serum LH and FSH concentrationsCanadian Journal of Physiology and Pharmacology, 1977
- Effects of naloxone, morphine and methionine enkephalin on serum prolactin, luteinizing hormone, follicle stimulating hormone, thyroid stimulating hormone and growth hormoneLife Sciences, 1977
- Stimulation of prolactin release in the rat by intraventricular injection of β-end orphin and methionine-enkephalinBiochemical and Biophysical Research Communications, 1977
- Changes with Age in Levels of Serum Gonadotropins, Prolactin, and Gonadal Steroids in Prepubertal Male and Female RatsEndocrinology, 1975
- Estrogenic Regulation of Cytoplasmic Receptor Populations in Estrogen-Responsive Tissues of the RatEndocrinology, 1974
- Pituitary Responsiveness to LH-Releasing Hormone in Intact Female Rats of Different Ages*Endocrinology, 1972
- Studies on the Pituitary Responsiveness to Luteinizing Hormone-Releasing Hormone (LH-RH) in Intact Male Rats of Different AgesEndocrinology, 1972
- Multiple Range and Multiple F TestsPublished by JSTOR ,1955